From 2021 to 2023, more than 105,000 people in the U.S. died from a drug overdose each year — tens of thousands more than the already high rates seen in the lead-up to the Covid pandemic. Then, suddenly, the death rates dropped.

In 2024, U.S. overdose deaths decreased 27%. Preliminary data from 2025 show another meaningful drop, though overdose mortality is still quite high. Other countries with major overdose problems also saw fewer deaths: In Scotland, there was a 13% decrease in 2024, and in Canada, 9%. 

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